What's up

You're looking a bit miserable. What's up?

I got a call saying to come straight away. What's up?

Hello, what's up? Don't cry, bub. What's the trouble?

"What's up?" he asked, dropping back into a chair, and jingling the loose coins in his trouser pockets. / "I have had news of the Black Eagle," his father answered. "She is reported from Madeira."

Lady Frederick: Oh lord, I wish I were eighteen. [She sinks into a chair, and an expression of utter weariness comes over her face.] Gerald: I say, what's up? Lady Frederick: [Starting.] I thought you'd gone. Nothing.

Hey, what's up? – Not much, just working.

Hey, what's up? – Hey! Good to see you.